Diltiazem : substance active à effet thérapeutique - VIDAL (2024)

FAQs

What is the best time of day to take diltiazem? ›

How to use diltiazem oral. Take this medication by mouth before meals and at bedtime as directed by your doctor, usually 3 to 4 times a day. The dosage is based on your medical condition, response to treatment, and other medications you may be taking.

Distribution: Diltiazem is 70% to 80% bound to plasma proteins. Excretion: The plasma elimination half-life following drug administration is about 3.0 to 4.5 hours. Diltiazem undergoes extensive metabolism in which 2% to 4% of the unchanged drug appears in the urine.

This drug may cause rare orbital and ocular symptoms. We report a case of bilateral proptosis and periorbital edema that developed as side effects of diltiazem treatment and discuss the possible mechanism of the ocular side effects.

If you take too much

Too much diltiazem can make you feel faint, dizzy or sleepy. This is because it can cause your heart to beat irregularly.

Drinking grapefruit juice or consuming the fruit can cause a clinically significant increase in systemic exposure to diltiazem. Clinically, there does not seem to be a significant impact on blood pressure, but caution should be used when consuming grapefruit and taking diltiazem.

Using dilTIAZem together with multivitamin with minerals can decrease the effects of dilTIAZem. Talk with your doctor before using dilTIAZem and multivitamin with minerals together. You may need a dose adjustment or need your blood pressure checked more often if you take both medications.

The current study showed that 30 mg kg^-1 of DTZ impaired retention and retrieval of young mice memory. The 30 mg kg^-1 of DTZ enhanced retention and retrieval while 10 mg kg^-1 of it improved retrieval of aged mice memory.

Common diltiazem side effects include headaches, dizziness, and swelling. Constipation, a slow heart rate, and low blood pressure are also possible. Diltiazem can potentially worsen heart failure symptoms. Because of this, certain people with heart failure should avoid taking it.

Diltiazem is used to treat high blood pressure and to control angina (chest pain). Diltiazem is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart.

High blood pressure: The typical starting dose ranges from 120 mg to 240 mg by mouth once daily, depending on which product you're prescribed. The typical maintenance dose ranges from 120 mg to 540 mg daily.

Is 180 mg of diltiazem a lot? ›

For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose as needed.

Some side effects of diltiazem may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

However, it's best to not drink alcohol for a few days after starting diltiazem or if your doctor increases your dose.

Common side effects include swollen hands, ankles or feet, a pounding heartbeat (palpitations) and constipation. If diltiazem makes you feel dizzy or drowsy, do not drive a car, ride a bike, or use tools or machinery until you feel better.

Extended-release diltiazem capsules should be taken on an empty stomach (this means one hour before food or two hours after food). Most other diltiazem formulations can be taken either with or without food; however, you should always check the instructions on the label.